Anti-Nöronal Nükleer Antikor-Tip1 (ANNA-1; Anti-HU)
Sanal Hastane||1 dk okuma
Klinik kullanımı :
Paraneoplastik otoimmün nöropatiler, ensefelomyeloradikülopatiler
ve küçük hücreli akciğer kanseri ile ilişkili pseudoobstrüksiyonlar ve
dismotilitelerin değerlendirilmesinde kullanılır.
Referans değerler
Negatif (Serum) : < 1:60
Negatif (BOS) : < 1:2
Titre >1:480 ise Western Blot ile saptanabilir.
Yükseldiği durumlar
Sigara içenlerde Anti-Hu pozitifliği görülebilir.
#ensefelomyeloradikülopatiler#küçük hücreli akciğer kanseri#Paraneoplastik otoimmün nöropatiler#sigara
Kaynaklar ve Referanslar
- [1]Gupta N, Yuil-Valdes A, Piccione EA. “Anti-Hu (ANNA-1) Associated Paraneoplastic Sensory Neuronopathy in a Large Cell Neuroendocrine Carcinoma of the Lung.”. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2023. PMID: 35272731. PubMed →
- [2]DiMauro KA, Thompson NR, Lapin B, Pennell NA, Stevens G, Shook S, Cohen JA, Kunchok A. “Progressive disability but survival advantage in anti-Hu/ANNA1 paraneoplastic neurological syndromes.”. Journal of Neurology. 2026. PMID: 42233990. PubMed →
- [3]Gilligan M, Thakolwiboon S, Orozco E, et al. “Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria.”. Annals of clinical and translational neurology. 2025. PMID: 39708293. PubMed →
- [4]Chen JN, Leung ECH, Jiang K, Cunningham JM. “Anti-Hu paraneoplastic syndrome with gastrointestinal dysmotility associated with nasopharyngeal squamous cell carcinoma and small bowel adenocarcinoma.”. BMJ Case Reports. 2026. PMID: 41839521. PubMed →
- [5]Narayan RN, McKeon A, Fife TD. “Autoimmune Vestibulocerebellar Syndromes.”. Seminars in neurology. 2020. PMID: 31958862. PubMed →
- [6]Chen J, Wang X, Zhang J, Wang Y, Hu W. “Epilepsia partialis continua may be a rare electroclinical feature of anti-Hu encephalitis: a pediatric case report.”. Frontiers in Pediatrics. 2026. PMID: 42099514. PubMed →
