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BOS’ta Oligoklonal Bant Araştırması

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BOS’ta Oligoklonal Bant Araştırması

Klinik kullanımı :

Santral sinir sisteminin enflamatuar (menenjit, SSS sfilizi) ve otoimmün hastalıklarında özellikle Multiple skleroz (MS) ve santral sinir sistemi tanısında kullanılır. MS ve Amyotrofik Lateral Skleroz gibi demiyelizan hastalıklarda, myelinin bir komponenti olan myelin-basic-protein artışı görülür.

Referans değerler

Negatif

#Amyotrofik Lateral Sklero#menenjit#Multiple skleroz (MS)#SSS sfilizi

Kaynaklar ve Referanslar

  1. [1]Thompson AJ, Banwell BL, Barkhof F, et al. “Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.”. The Lancet. Neurology. 2018. PMID: 29275977. PubMed →
  2. [2]Scharf A, Cohen JA, Marrie RA, Miller AE, Waubant E, Kilbane M, et al.. “Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study.”. Neurology. 2026. PMID: 42284534. PubMed →
  3. [3]Carta S, Ferraro D, Ferrari S, et al. “Oligoclonal bands: clinical utility and interpretation cues.”. Critical reviews in clinical laboratory sciences. 2022. PMID: 35277112. PubMed →
  4. [4]Manin A, Ingenito F, Cores EV, Alarcón Guerrero D, Ramos SG, Villa AM. “Kappa free light chain index in multiple sclerosis and other inflammatory CNS diseases: a pilot single-center study from Argentina.”. Frontiers in Immunology. 2026. PMID: 42292422. PubMed →
  5. [5]Hegen H, Arrambide G, Gnanapavan S, et al. “Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement.”. Multiple sclerosis (Houndmills, Basingstoke, England). 2023. PMID: 36527368. PubMed →
  6. [6]Higgins V, Parker ML, Ahmed B, Bhayana V, Booth RA, Chen Y, et al.. “Best practice recommendations for laboratory analysis and reporting of cerebrospinal fluid oligoclonal banding and associated tests for multiple sclerosis (MS): a consensus report from the harmonized CSF analysis for MS investigation (hCAMI) subcommittee of the Canadian society of clinical chemists (CSCC).”. Clinical Biochemistry. 2026. PMID: 41692184. PubMed →
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