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Diazepam

Sanal Hastane||1 dk okuma
Diazepam

Klinik kullanımı :

Hemen geleneksel antikonvülzan tedaviye cevap vermeyen ani

gelişen konvulsif epileptik atakların tedavisinde kullanılır.

Benzodiazepin (Diazepam=Valium®) bir prototiptir ve yaygın olarak

antianksiyete, hipnotik ve kas gevşetici ajan olarak kullanılır.

Referans değerler

Tedavi Dozları

Diazepam : 0.2-0.8 μg/ml

Nordiazepam : 0.2-0.8 μg/ml

Her İkisi Toplam : 0.4-1.8 μg/ml

Toksik Doz :

Her İkisi Toplam : ≥ 5.0 μg/ml

#Benzodiazepin#Diazepam#epileptik atak

Kaynaklar ve Referanslar

  1. [1]Greenblatt DJ, Harmatz JS, Shader RI. “Diazepam in the Elderly: Looking Back, Ahead, and at the Evidence.”. Journal of clinical psychopharmacology. 2020. PMID: 32332456. PubMed →
  2. [2]Seker Gezici M, Turan C, Ayyildiz Emecen D, Kanmaz S, Isik E, Yurtseven A, Atik T, Yilmaz SK, Tekgul H, Saz EU. “Intravenous diazepam application in a departmental convulsive status epilepticus protocol with CYP2C19 polymorphisms: a pediatric prospective cohort study.”. BMC pharmacology & toxicology. 2026. PMID: 42249455. PubMed →
  3. [3]“Diazepam and breathlessness.”. Lancet (London, England). 1980. PMID: 6105401. PubMed →
  4. [4]O'Keefe M, Feih J, Feldman R, Stanton M, Dang CH. “Optimization of benzodiazepine use for status epilepticus in the emergency department.”. The American journal of emergency medicine. 2026. PMID: 42013624. PubMed →
  5. [5]Verrotti A, Milioni M, Zaccara G. “Safety and efficacy of diazepam autoinjector for the management of epilepsy.”. Expert review of neurotherapeutics. 2015. PMID: 25614951. PubMed →
  6. [6]Kertam A, Hatem N, Al-Azzawi OM, Tu LH, Harb A, Hassanin MS, Abdeen I, Mostafa M, Allam S, Mostafa M, Nabil Y. “Efficacy, safety, route of administration of midazolam and diazepam for pediatric status epilepticus: systematic review, meta-analysis, and trial sequential analysis.”. Pediatric research. 2026. PMID: 41904318. PubMed →
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