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Valproik Asit (Depakin,Convulex)

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Valproik Asit (Depakin,Convulex)

Referans değerler

Total :

Tedavi dozu : 40(Devamlı doz)-100 (pik) μg/ml

Toksik Doz : ≥ 120 μg/ml

Serbest :

Tedavi dozu : 4-15 μg/ml

Toksik Doz : ≥ 15 μg/ml

Klinik kullanımı :

Antiepileptik ilaçtır. Tedavinin takibinde kullanılır. Olası toksisitenin

saptanmasında kullanılır.

 

 

#Antiepileptik ilaç#Convulex#Depakin#epilepsi#havale#sara nöbeti

Kaynaklar ve Referanslar

  1. [1]Parys W, Pyka-PajÄ…k A. “Use of TLC-Densitometric Method for Determination of Valproic Acid in Capsules.”. Molecules (Basel, Switzerland). 2022. PMID: 35164016. PubMed →
  2. [2]Abd-Eldayem AM. “Valproic acid: Mechanistic insights into neuronal actions, epigenetic modulation, and clinical risk.”. Current opinion in pharmacology. 2026. PMID: 42001774. PubMed →
  3. [3]Auff E, Holzner F, Wessely P. “[Further therapeutic possibilities with valproic acid (Convulex)].”. Wiener medizinische Wochenschrift (1946). 1985. PMID: 3933186. PubMed →
  4. [4]Wartman C, VandenBerg A. “Valproate: Not All Boxed Warnings Are Created Equal.”. The Annals of pharmacotherapy. 2022. PMID: 35392666. PubMed →
  5. [5]Lunke S, Maxwell S, Khurana I, et al. “Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.”. Clinical epigenetics. 2021. PMID: 33743782. PubMed →
  6. [6]Deng X, Tu X, Yang S, Xiong J, Yang Y, Jiang S. “Sodium Valproate-Associated Thrombocytopenia in Antiepileptic Drug Polypharmacy: A Case Report and Review of the Literature.”. The American journal of case reports. 2025. PMID: 41272959. PubMed →
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