Adenozin Deaminaz (ADA)

Klinik kullanımı : Malignitelerin ve enfeksiyonların birçok değişik tipinde (viral hepatit,
infeksiyoz mononükleoz, tifoid fever ve tüberküloz), portal hipertansiyonla (asit) ilişkili karaciğer sirozunda en faydalı test ADA’dır.
Plevral sıvıda yükselmiş ADA seviyeleri çok yaygın olarak Tüberküloz (TB) ile ilişkilidir. Efüzyonlarda bulunan artmış ADA aktivitesi; TB;
bakteriyel enfeksiyonlar, romatolojik hastalıklar, lenfoproliferatif bozukluklarda görülür. BOS’da ADA; tüberküloz menenjit olgularında yüksektir.
Referans değerler : < 30 U/L
Yükseldiği durumlar:
-Hepatit, siroz, hemokromatoz,
-Hemolitik anemi,
-Tüberküloz,
-Prostat ve mesane karsinomları,
-Talasemi majör,
-Otoimmün hastalıklar,
-Gut,
-Enfeksiyoz mononükleoz,
-Kalp yetmezliği,
-Sarkoidoz.
Kaynaklar ve Referanslar
- [1]Bradford KL, Moretti FA, Carbonaro-Sarracino DA, et al. “Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations.”. Journal of clinical immunology. 2017. PMID: 28842866. PubMed →
- [2]Bradford KL, Moretti FA, Carbonaro-Sarracino DA, et al. “Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations.”. Journal of clinical immunology. 2017. PMID: 28842866. PubMed →
- [3]Ilhan U, Guney Z, Ozcelik A, Kaya HS, Cetinkaya E, Cortuk M. “Diagnostic value of biochemical ratios in the differential diagnosis of tuberculous and malignant pleural effusions.”. BMC pulmonary medicine. 2026. PMID: 42399924. PubMed →
- [4]Kohn DB, Gaspar HB. “How We Manage Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA SCID).”. Journal of clinical immunology. 2017. PMID: 28194615. PubMed →
- [5]Kohn DB, Gaspar HB. “How We Manage Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA SCID).”. Journal of clinical immunology. 2017. PMID: 28194615. PubMed →
- [6]Mashalkar SM, Sontakke A, Ali S, Kumbhare Y, Ghule P. “Low Adenosine Deaminase (ADA) Does Not Exclude Tuberculosis: A Case of Loculated Pleural Effusion Diagnosed by a Medical Thoracoscopic Pleural Biopsy.”. Cureus. 2026. PMID: 42281690. PubMed →
- [7]Fournier S, Dauvilliers Y, Warby SC, et al. “Does the adenosine deaminase (ADA) gene confer risk of sleepwalking?”. Journal of sleep research. 2022. PMID: 34913218. PubMed →
- [8]Fournier S, Dauvilliers Y, Warby SC, et al. “Does the adenosine deaminase (ADA) gene confer risk of sleepwalking?”. Journal of sleep research. 2022. PMID: 34913218. PubMed →
- [9]Gao Y, Hai L, Niu Y, Zhu HZ, Niu R, Tian QF, Wang QJ, Hao YL, Wen JX, Xu YN, Hu ZD, Zheng WQ, Zhang L. “Comparison of the diagnostic accuracy of interleukin-27 and adenosine deaminase for tuberculous pleural effusion: A systematic review and meta-analysis with head-to-head design.”. Cytokine. 2026. PMID: 41747349. PubMed →

