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Anti-Sentromer Antikor (ACA)

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Anti-Sentromer Antikor (ACA)

Klinik kullanımı :

Hep2 hücreleri üzerinde belirgin immunofloresans veren

otoantikorlardır. CREST Sendromlu hastalarda (Kalsinozis,

Raynoud’s fenomeni, Özafageal hipomotilite, Sklerodaktili ve

Telenjektazi) bu otoantikorlar saptanmıştır.

Referans değerler

Negatif

Zayıf pozitif : Tarama Titresi (1:40 Hep-2 Cells)

(1:20 Kidney Cells)

Orta derecede pozitif : Tarama titresinin bir dilusyonu

Güçlü pozitif : Tarama titresinin iki dilusyonu

#CREST sendromu#Kalsinozis#Özafageal hipomotilite#Raynoud’s fenomeni#Sklerodaktili#Telenjektazi

Kaynaklar ve Referanslar

  1. [1]Saito M, Akutsu N, Numata Y, et al. “Development of anti-centromere antibody-positive autoimmune hepatitis after childbirth.”. Clinical journal of gastroenterology. 2020. PMID: 31960389. PubMed →
  2. [2]Ando Y, Mabuchi S, Mataki N, Nakayama S, Honda A, Kamiya M, Yasuda S, Takeo H, Aono S, Hashimoto M, Harada K, Murashima N. “Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report.”. Journal of medical case reports. 2025. PMID: 40764937. PubMed →
  3. [3]Lee KE, Kang JH, Lee JW, et al. “Anti-centromere antibody-positive Sjögren's syndrome: A distinct clinical subgroup?”. International journal of rheumatic diseases. 2015. PMID: 26179502. PubMed →
  4. [4]Gupta P, Adhikari P, Sitaula D, Thapa SJ, Thapa M. “Epigastric discomfort in a young woman: unveiling a case of CREST syndrome.”. Annals of medicine and surgery (2012). 2024. PMID: 39525714. PubMed →
  5. [5]Tsukamoto M, Suzuki K, Takeuchi T. “Clinical and Immunological Features of Anti-centromere Antibody-Positive Primary Sjögren's Syndrome.”. Rheumatology and therapy. 2018. PMID: 30255483. PubMed →
  6. [6]Arana-Guajardo A, Villarreal-Alarcón M. “CREST Syndrome: Clinical Expression of the Disease.”. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2017. PMID: 28742726. PubMed →
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