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Otoimmün Hastalıkların Tanısı İçin Test Paneli

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Otoimmün Hastalıkların Tanısı  İçin Test Paneli

Klinik kullanımı

Bu panel;

-Karışık Konnektif Doku Hastalıklarında,

-Sistemik Lupus Eritematosus (SLE),

-Sjögren Sendromu,

-CREST Sendromu (Kalsinosis, Raynoud’s Sendromu, özefageal disfonksiyon, Sklerodaktili ve telanjiektazi),

-İdiopatik Raynaud’s Sendromu,

-İlaç nedenli lupus,

-ANA negatif lupus,

-Diffüz skleroderma vs. taraması ve otoimmun bozukluklar tanısında kullanılır. Ayrıca otoimmün tiroidit, Romatoid artrit ve atipik otoimmün bozukluklarda kullanılır.

Yöntem

Antinükleer Antikor (ANA)                                  IFA/IMAGE <7,5 IU/ml

ANA patern                                                      IFA

  1. DNA Otoantikoru                                         Farr RBA <5.0 IU/ml

n RNP/sm IgG otoantikoru                                 EIA <5.0 units

Sm (smith) IgG otoantikoru                               EIA <5.0 units

SS-A IgG otoantikoru                                        EIA <5.0 units

SS-B IgG otoantikoru                                         EIA <5.0 units

Scl-70 IgG otoantikoru                                       EIA <5.0 units

Ribozomal P protein otoantikoru                          EIA <5.0 units

Tiroid Peroksidaz otoantikoru                              ICMA <60 U/ml

C3 Komplemanı                                                  Türbidimetrik 82-235 mg/dl

C4 Komplemanı                                                  Türbidimetrik 16-70 mg/dl

Romatoid faktör                                                 Türbidimetrik <60 IU/ml

 

 

Kaynaklar ve Referanslar

  1. [1]Garden OA, Kidd L, Mexas AM, et al. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats.”. Journal of veterinary internal medicine. 2019. PMID: 30806491. PubMed →
  2. [2]Abel G, Ansari MQ, Snyder MR, Tebo AE, Wener MH, Naides SJ. Historical Perspective on Antinuclear Antibody Testing.”. The Journal of Rheumatology. 2025. PMID: 39892879. PubMed →
  3. [3]Banwell B, Bennett JL, Marignier R, et al. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria.”. The Lancet. Neurology. 2023. PMID: 36706773. PubMed →
  4. [4]Almaabdi K, Ahmad Z, Johnson SR. Advanced Autoantibody Testing in Systemic Sclerosis.”. Diagnostics (Basel). 2023. PMID: 36899995. PubMed →
  5. [5]Johnson SR, Bernstein EJ, Bolster MB, et al. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.”. Arthritis & rheumatology (Hoboken, N.J.). 2024. PMID: 38973714. PubMed →
  6. [6]Duff D, Vyas N, Enderle J, Rajendran R. Evaluation of Antinuclear Antibody and Subserology Reflex Testing for the Diagnosis of Systemic Autoimmune Rheumatic Disorders in an Academic Teaching Hospital.”. Laboratory Medicine. 2023. PMID: 36779504. PubMed →
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