Otoimmün Hastalıkların Tanısı İçin Test Paneli

Klinik kullanımı
Bu panel;
-Karışık Konnektif Doku Hastalıklarında,
-Sistemik Lupus Eritematosus (SLE),
-Sjögren Sendromu,
-CREST Sendromu (Kalsinosis, Raynoud’s Sendromu, özefageal disfonksiyon, Sklerodaktili ve telanjiektazi),
-İdiopatik Raynaud’s Sendromu,
-İlaç nedenli lupus,
-ANA negatif lupus,
-Diffüz skleroderma vs. taraması ve otoimmun bozukluklar tanısında kullanılır. Ayrıca otoimmün tiroidit, Romatoid artrit ve atipik otoimmün bozukluklarda kullanılır.
Yöntem
Antinükleer Antikor (ANA) IFA/IMAGE <7,5 IU/ml
ANA patern IFA
- DNA Otoantikoru Farr RBA <5.0 IU/ml
n RNP/sm IgG otoantikoru EIA <5.0 units
Sm (smith) IgG otoantikoru EIA <5.0 units
SS-A IgG otoantikoru EIA <5.0 units
SS-B IgG otoantikoru EIA <5.0 units
Scl-70 IgG otoantikoru EIA <5.0 units
Ribozomal P protein otoantikoru EIA <5.0 units
Tiroid Peroksidaz otoantikoru ICMA <60 U/ml
C3 Komplemanı Türbidimetrik 82-235 mg/dl
C4 Komplemanı Türbidimetrik 16-70 mg/dl
Romatoid faktör Türbidimetrik <60 IU/ml
Kaynaklar ve Referanslar
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- [3]Banwell B, Bennett JL, Marignier R, et al. “Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria.”. The Lancet. Neurology. 2023. PMID: 36706773. PubMed →
- [4]Almaabdi K, Ahmad Z, Johnson SR. “Advanced Autoantibody Testing in Systemic Sclerosis.”. Diagnostics (Basel). 2023. PMID: 36899995. PubMed →
- [5]Johnson SR, Bernstein EJ, Bolster MB, et al. “2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.”. Arthritis & rheumatology (Hoboken, N.J.). 2024. PMID: 38973714. PubMed →
- [6]Duff D, Vyas N, Enderle J, Rajendran R. “Evaluation of Antinuclear Antibody and Subserology Reflex Testing for the Diagnosis of Systemic Autoimmune Rheumatic Disorders in an Academic Teaching Hospital.”. Laboratory Medicine. 2023. PMID: 36779504. PubMed →


