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ENA Antikorları (Ekstrakte Edilebilir Nükleer Antijen Antikorları) (Sm,ss-A,ss-B)

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ENA Antikorları (Ekstrakte Edilebilir Nükleer Antijen Antikorları) (Sm,ss-A,ss-B)

Klinik kullanımı :

SLE ve Sjögren sendromunun ayrılması dahil bağ dokusu

hastalıklarının (SLE, miks bağ dokusu hastalığı, Sjögren sendromu,

skleroderma, dermatomyozit ve polimyozit) ayrımı ve tanısında

kullanılır. Ortak özellikleri ekstrakte edilebilen nükleer antikor

olmalarıdır.

Referans değerler

< 20 Unit (Negatif)

20-25 Unit (Sınırda)

≥26 Unit (Pozitif)

#Dermatomyozit#polimyozit#Sjögren sendromu#Skleroderma#SLE

Kaynaklar ve Referanslar

  1. [1]Furukawa F, Kashihara-Sawami M, Lyons MB, et al. “Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus.”. The Journal of investigative dermatology. 1990. PMID: 2132545. PubMed →
  2. [2]Fauchais AL, Martel C, Gondran G, Lambert M, Launay D, Jauberteau MO, Hachulla E, Vidal E, Hatron PY. “Immunological profile in primary Sjogren syndrome: clinical significance, prognosis and long-term evolution to other auto-immune disease.”. Autoimmunity Reviews. 2010. PMID: 20457283. PubMed →
  3. [3]Sánchez-Guerrero J, Lew RA, Fossel AH, et al. “Utility of anti-Sm, anti-RNP, anti-Ro/SS-A, and anti-La/SS-B (extractable nuclear antigens) detected by enzyme-linked immunosorbent assay for the diagnosis of systemic lupus erythematosus.”. Arthritis and rheumatism. 1996. PMID: 8651971. PubMed →
  4. [4]Kramer K, Pecher AC, Henes J, Klein R. “IgE autoantibodies to nuclear antigens in patients with different connective tissue diseases: re-evaluation and novel findings.”. Frontiers in Immunology. 2025. PMID: 40181984. PubMed →
  5. [5]Omagari K, Ohba K, Kadokawa Y, et al. “Anti-extractable nuclear antigens (ENA) antibodies in patients with chronic hepatitis C before and after treatment with interferon.”. Autoimmunity. 2003. PMID: 14567556. PubMed →
  6. [6]Sharmin S, Ahmed S, Abu Saleh A, Rahman F, Choudhury MR, Hassan MM. “Association of Immunofluorescence pattern of Antinuclear Antibody with Specific Autoantibodies in the Bangladeshi Population.”. Bangladesh Medical Research Council Bulletin. 2014. PMID: 26415344. PubMed →
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