Metotreksat
Sanal Hastane||1 dk okuma
Klinik kullanimi
Ilaç düzeyinin takibinde kullanilir. Metotreksat, yüksek dozlarda kanser tedavisinde kullanilir.
Referans degerler
4-6 saatte 50 mg/m2-15 g/m2 doz IV infüzyon seklinde uygulandiginda;
Tedavi Dozu
24.saatte 5,00-10,0 µmol/L
48.saatte 0,5-1,0µmol/L
72.saatte <0,2 µmol/L
Toksik Dozu
24.saatte >10,0 µmol/L
48.saatte >1,0 µmol/L
72.saatte >0,2 µmol/L
Bu yazı hekim incelemesinden geçmektedir; tanı ve tedavi için hekiminize başvurun.
#astım#Chron hastalığı#Juvenil Romatoid artrit#kanser tedavisi#polimyozit#Psöriatik artrit#Reiter sendromu#Romatoid Artrit
Kaynaklar ve Referanslar
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- [2]Zhao Z, Hua Z, Luo X, et al.. “Application and pharmacological mechanism of methotrexate in rheumatoid arthritis.”. Biomedicine & Pharmacotherapy. 2022. PMID: 35658215. PubMed →
- [3]Dabkowska B, Dabkowski J. “[Methotrexate--mechanism of action and application].”. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2001. PMID: 11852822. PubMed →
- [4]Friedman B, Cronstein B. “Methotrexate mechanism in treatment of rheumatoid arthritis.”. Joint Bone Spine. 2018. PMID: 30081197. PubMed →
- [5]StyczyÅ„ski J, Wysocki M. “[Methotrexate resistance in acute leukemias].”. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2001. PMID: 11757224. PubMed →
- [6]Cronstein BN, Aune TM. “Methotrexate and its mechanisms of action in inflammatory arthritis.”. Nature Reviews Rheumatology. 2020. PMID: 32066940. PubMed →
