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Akut Lösemi Paneli (ALL)

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Akut Lösemi Paneli (ALL)


Klinik kullanımı :

Akut lösemi başlıca iki gruba ayrılır; Akut lenfositik lösemi (ALL) ve

akut non lenfositik lösemi (ANLL). Ancak daha sonraları

hematologlar FAB sınıflandırması yapmışlardır. Buna göre;

Referans değerler

Her olgu hematopatolog tarafından, immunofenotipik bulgular ve

morfolojik özellikler ile korelasyon yapılarak yorumlanmalıdır.

Akut lenfositik lösemi (ALL)

L1 : Akut lenfoblastik lösemi (çocukluk ALL)

L2 : Akut lenfoblastik lösemi (yetişkin ALL)

L3 : Akut lenfoblastik lösemi (Burkitt tipi)

Akut non-lenfositik lösemi (ANLL)

M0 : Akut myeloblastik lösemi (minimal diferansiasyonlu)

M1 : Akut myeloblastik lösemi (maturasyonsuz)

M2 : Akut myeloblastik lösemi (maturasyonlu)

M3 : Akut promyelositik lösemi (genel tip)

*M3V *Mikrogranüler varyant

M4 : Akut myelomonositik lösemi (genel tip)

*M4eo *Anormal eozinofilli

M5 : Akut monositik lösemi

*M5a *Zayıf diferansiasyonlu

*M5b *Diferansiye

M6 : Akut eritrolösemi

*M6a *Eritrolösemi

*M6b *Pure eritroid malignansi

M7 : Akut megakaryoblastik lösemi

#eritrolösemi#Lösemi#megakaryoblastik lösemi#monositik lösemi#myeloblastik lösemi#myelomonositik lösemi#promyelositik lösemi

Kaynaklar ve Referanslar

  1. [1]Wang ES, Issa GC, Erba HP, et al. “Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial.”. The Lancet. Oncology. 2024. PMID: 39362248. PubMed →
  2. [2]Pölönen P, Teachey DT, Mullighan CG. “Genomic Insights into the Biology of T-lineage Acute Lymphoblastic Leukemia.”. Blood Cancer Discov. 2026. PMID: 41954523. PubMed →
  3. [3]Duncavage EJ, Bagg A, Hasserjian RP, et al. “Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.”. Blood. 2022. PMID: 36130297. PubMed →
  4. [4]Nafady-Hego H, Flemban A, Kabrah S, et al.. “Immunophenotypic Profiling of Lymphocyte Subsets in Children and Adolescents With Acute Lymphoblastic Leukaemia: Immune Dysregulation Before and After Remission.”. J Immunol Res. 2026. PMID: 42394164. PubMed →
  5. [5]Matarraz S, Almeida J, Flores-Montero J, et al. “Introduction to the diagnosis and classification of monocytic-lineage leukemias by flow cytometry.”. Cytometry. Part B, Clinical cytometry. 2017. PMID: 26282340. PubMed →
  6. [6]Rivera-Orcoapaza C, Rosales-Rimache J. “Diagnostic performance of DNA index for detection of high hyperdiploidy in childhood B-cell acute lymphoblastic leukemia.”. PLoS One. 2026. PMID: 42008504. PubMed →
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