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Salisilat (ASA,Asetilsalisilik Asit,Aspirin)

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Salisilat (ASA,Asetilsalisilik Asit,Aspirin)

Klinik Kullanımı

Aspirin analjezik, antienflamatuar ve antipiretik olarak kullanılır. Tedavi dozunun optimize edilmesi, toksisite vakalarının teşhis ve takibinde kullanılır.

Referans değerler

Analjezik konsantrasyon: 2-10 mg/dl

Antienflamatuar konsantrasyon: 15-30 mg/dl

Toksik konsantrasyon: > 30 mg/dl

 

 

#Aspirin zehirlenmesi#Salisilat zehirlenmesi

Kaynaklar ve Referanslar

  1. [1]Rolando B, Lazzarato L, Donnola M, et al. “Water-soluble nitric-oxide-releasing acetylsalicylic acid (ASA) prodrugs.”. ChemMedChem. 2013. PMID: 23754790. PubMed →
  2. [2]O'Keefe M, Stanton M, Feldman R, Theobald J. “Incidence of rebound salicylate toxicity following cessation of urine alkalinization.”. Clinical toxicology (Philadelphia, Pa.). 2023. PMID: 37427892. PubMed →
  3. [3]Kowalski K. “Insight into the Biological Activity of Organometallic Acetylsalicylic Acid (Aspirin) Derivatives.”. ChemPlusChem. 2019. PMID: 31939218. PubMed →
  4. [4]Sepulveda RA, Ortega M, Donoso N, Jara A. “[Physiopathology and management of acetylsalicylic acid intoxication].”. Revista medica de Chile. 2018. PMID: 30725045. PubMed →
  5. [5]Zimmermann P, Curtis N. “The effect of aspirin on antibiotic susceptibility.”. Expert opinion on therapeutic targets. 2018. PMID: 30244614. PubMed →
  6. [6]Ciejka M, Nguyen K, Bluth MH, Dubey E. “Drug Toxicities of Common Analgesic Medications in the Emergency Department.”. Clinics in laboratory medicine. 2016. PMID: 27842792. PubMed →
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